This is a curious syndrome as not much information can be found about it.
Information so far:
- it seems to be connected to thyroid conditions specifically hypothyroid
- it occurs in adults
- in children it is called something different - Kocher-Debré-Semélaigne syndrome (which seems more severe)
- it is considered a type of myopathy
- it was named after Johann Hoffmann the German neurologist, born in 1857, who also named other medical things
- associated with myxedema - a rare, life-threatening condition due to long-term, undiagnosed hypothyroidism - symptoms are "intense cold intolerance and drowsiness followed by profound lethargy and unconsciousness" CNN Hypothyroidism
- associated with pseudomyotonia
- painful cramps and spasms
- "Hypothyroidism presenting as muscle stiffness and pseudohypertrophy is called 'Hoffman's syndrome'" from Hoffman's Syndrome: Muscle Stiffness, Pseudohypertrophy and Hypothyroidism. Mastropasqua M, Spagna G, Baldini V, Tedesco I, Paggi A
- enlarged calf muscle
- muscle pain
- muscle stiffness
- muscle cramps
- muscle spasms
- cold makes symptoms worse
- pseudomyotonic reflexes which is delayed relaxation of the deep tendon reflexes
"muscular symptoms are common in hypothyroid patients (varying from myalgia, weakness, stiffness, cramps and easy fatigability in 30-80% of patients), muscular hypertrophy with muscle stiffness is reported in less than 10% of the patients.Hoffmann's syndrome is a specific, rare form of hypothyroid myopathy, which causes proximal weakness and hypertrophy of muscles." from Hoffmann syndrome: Presentation in hypothyroidism JPGM - Journal of Post Graduate Medicine Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
"Muscle cramps, stiffness and weakness frequently seen in hypothyroidism are due to a primary myopathy.Muscle hypertrophy is a rare occurrence in hypothyroidism. It is more commonly seen in males than females and is referred as Hoffman's syndrome in adult " from Acquired ichthyosis with hoffman’s syndrome by Sathyanarayana BD, Leelavathi B
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report. Pubmed
Hoffman's Syndrome: Muscle Stiffness, Pseudohypertrophy and Hypothyroidism
M. Mastropasqua, G. Spagna, V. Baldini, I.Tedesco, A. Paggi
Muscle carnitine in hypo- and hyperthyroidism
, J. M. Gilchrist, MD, J.V. Hennessey, MD
, M. Kandula, MD
Hypothyroid myopathy with manifestations of Hoffman's syndrome and myasthenia gravis. Turker H, Bayrak O, Gungor L, Yilmaz A, Terzi M, Turker CM, Onar MK, Kahraman H.
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report. Vasconcellos, Peixoto, de Oliveira, Penque, Leite.
Primary Hypothyroidism from Medscape describes what happens in untreated hypothyroidism
I know absolutely nothing about medicine and have just collected articles and links that I find good and interesting. You must keep on seeking medical advice from a doctor or specialist to be diagnosed.